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ホーム  > 教員紹介  > 山本正彦

山本正彦

学生へ、あるいはこれから入学を目指す方へのメッセージ

脳科学とゲノム科学は21世紀に大いに発展が期待される領域であり、“21世紀の人間科学”の進展にとって2つの柱ということができます。運動学・健康スポーツ学・言語聴覚障害学を縦糸とすると、脳科学とゲノム科学は横糸的にこれらの学問を支えます。特に、言語聴覚士は言語・聴覚・認知などのコミュニケーションと生きるために重要な摂食嚥下のリハビリテーションに医療専門職として携わります。一対一で患者様と接して、人間の尊厳に深く関わるこれらの機能回復のために、検査・評価、訓練・指導・援助をおこないます。まさに人間科学の実践といえるでしょう。


今後増加する、痴呆(認知症)、高次脳機能障害のリハビリテーションは未開拓の領域です。若く、柔軟性と可塑性に富んだ脳で、問題解決への思考プロセスを学び、人間科学への興味を深め、実践へとつなげていきましょう。“免許があれば食える”という時代はいずれ終わり、ゲノムと同様に、研鑽を積んで進化する人だけが生き残れる淘汰の時代になります。

職位・学位・資格

教授、医師、医学博士、日本神経学会専門医・評議員、日本人類遺伝学会臨床遺伝専門医、日本リハビリテーション医学会専門医、日本内科学会認定内科医、日本医師会認定産業医

担当科目

音声言語聴覚系神経医学、臨床神経学、失語症、高次脳機能障害学、脳性麻痺・学習障害論、分子遺伝学、遺伝子診断学、プレセミナー

通常郵便の宛名

〒470-0195 日進市岩崎町阿良池12 愛知学院大学心身科学部健康科学科

最近の研究上の関心

ヒトの神経変性を一貫したテーマとして、ヒトヘルペスウイルスの発現解析から始まり、神経栄養因子等・病態関連分子発現解析、ニューロンの発現解析に至り、ヒトゲノムの解読を背景として、バイオインフォマティクスによる包括的・網羅的発現プロファイル解析へと発展している。また、脳血管障害や認知障害における痛覚認知を世界に先駆けて報告した。ホモサピエンスへのゲノム進化とともに、我々が獲得した言語は第2の進化といわれている。認知機能の一側面を担う言語機能が、転写制御下にある遺伝子発現システムに規定されるのか、ニューラルネットワークが規定するのか、あるいは両者か、複雑系の人間科学における今世紀最大のテーマの一つである。さらに、ヒトゲノムの解読完了から急速に進展している分子遺伝学を遺伝医学に還元し、いかに遺伝倫理に則って適切に遺伝医療を実践していくかが、もう一つの研究課題であり、これらを担う認定遺伝カウンセラーの養成も目指している。

最近の研究業績

Sawada K, Yamamoto M, Smith M, et al. Expression of EBNA-3 family in fresh B lymphocytes infected with EBV. Virology 168:22-30,1989
Yamamoto M, Smith M, Tanaka A, et al. Cycloheximide-resistant gene of EBV in freshly infected B lymphocytes. Virology 170:307-310,1989
Yamamoto M, Sobue G, Mei Li, et al. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and low-affinity nerve growth factor receptor (LNGFR) mRNA levels in cultured rat Schwann cells; differential time- and dose-dependent regulation by cAMP. Neurosci Lett 152:37-40,1993
Yamamoto M, Sobue G, Mutoh T, et al. Gene expression of high- and low-affinity nerve growth factor receptor in the adult and aged human peripheral nervous system. Neurosci Lett 158:39-43,1993
Yamamoto M, Sobue G, Mitsuma T, et al. cAMP-dependent differential regulation of extracellular matrix (ECM) gene expression in cultured rat Schwann cells. Brain Res 652:335-339,1994
Kachi T, Sobue G, Yamamoto M, et al. Sensory conduction study in chronic sensory ataxic neuropathy. J Neurol Neurosurg Psychiatry 57:941-944,1994
Yamamoto M, Kachi T, Igata A. Pain-related and electrically stimulated somatosensory evoked potentials in patients with stroke. Stroke 26:426-429,1995
Yamamoto M, Sobue G, Yamamoto K, et al. Expression of glial cell line-derived neurotrophic factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis. Neurosci Lett 204:117-120,1996
Yamamoto M, Sobue G, Mukoyama M, et al. Demonstration of slow acetylator phenotype of N-acetyltransferase in isoniazid neuropathy using an archival hematoxylin and eosin section of a sural nerve biopsy spcimen. J Neurol Sci 135:51-54,1996
Yamamoto M, Kachi T, Igata A. Pain-related evoked potentials in dementia. J Neurol Sci 137:117-119,1996
Tanaka F, Sobue G, Yamamoto M, et al. Differential pattern in tissue-specific somatic mosaicism of expanded CAG trinucleotide repeat in dentatorubral-pallidoluysian atrophy, Machado-Joseph disease and X-linked recessive spinal and bulbar muscular atrophy. J Neurol Sci 135:43-50,1996
Yamamoto M, Sobue G, Yamamoto K, et al. Expression of mRNAs for neurotrophins (NGF, BDNF, NT-3 and GDNF) and their receptors (p75, trkA, trkB and trkC) in the adult human peripheral nervous syetem and nonneural tissues. Neurochem Res 21:929-938,1996
Yamamoto M, Yasuda T, Hayasaka K, et al. Locations of crossover breakpoints within the CMT1A-REP repeat in Japanese patients with CMT1A and HNPP. Hum Genet 99:151-154,1997
Ikegami T, Ikeda H, Yamamoto M, et al. Facilitated diagnosis of the CMT1A duplication in chromosome 17p11.2-12: Analysis with a CMT1A-REP repeat probe and photostimulated luminescence imaging. Hum Mutat 9:563-566,1997
Yamamoto M, Kachi T, Sobue G. Pain-related and electrically stimulated somatosensory evoked potentials in patients with Machado-Joseph disease and multiple system atrophy. Intern Med 36:550-555,1997
Yamamoto M, Kachi T, Yamada T, et al. Sensory conduction study of cisplatin neuropathy: Preservation of small myelinated fibers. Intern Med 36:829-833,1997
Yamamoto M, Keller MP, Yasuda T, et al. Clustering of CMT1A duplication breakpoints in a 700 bp interval of the CMT1A-REP repeat. Hum Mutat 11:109-113,1998
Ito Y, Tanaka F, Yamamoto M, et al. Somatic mosaicism of the expanded CAG trinucleotide repeat in mRNAs for responsible gene of Machado-Joseph disease (MJD), dentatorubral-Pallidoluysian atrophy (DRPLA), and spinal and bulbar muscular atrophy. Neurochem Res 23:25-32,1998
Li M, Miwa S, Yamamoto M, et al. Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy. Ann Neurol 44:249-254,1998
Ichimura M, Yamamoto M, Kobayashi Y, et al. Tissue distribution of pathological lesions and Hu antigen expression in paraneoplastic sensory neuronopathy. Acta Neuropathol 95:641-648,1998
Mizuno K, Nagamatsu M, Yamamoto M, et al. Chronic inflammatory demyelinating polyradiculoneuropathy with diffuse and massive peripheral nerve hypertrophy: distinctive clinical and magnetic resonance imaging features. Muscle Nerve 21:805-808,1998
Sobue G, Yamamoto M, Doyu M, et al. Expression of mRNAs for neurotrophic factor (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trkA, trkB, and trkC) in human peripheral neuropathies. Neurochem Res 23:821-829,1998
Yamamoto M, Li M, Nagamatsu M, et al. Expression of low-affinity neurotrophin receptor p75NTR in the peripheral nervous system of human neuropathies. Acta Neuropathol 95:597-604,1998
Ito Y, Yamamoto M, Li M, et al. Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRa, LIFRb, IL-6a and gp130) in injured peripheral nerves. Brain Res 793:321-327,1998
Yamamoto M, Mitsuma N, Ito Y, et al: Expression of GDNF and GDNFR-a mRNAs in human peripheral neuropathies. Brain Res 809:175-180,1998
Mutoh M, Li M, Yamamoto M, et al. Differential signaling cascade of MAP kinase and S6 kinase depends on 3', 5'-monophosphate concentration in Schwann cells: correlation to cellular differentiation and proliferation. Brain Res 810:274-278,1998
Mitsuma N, Yamamoto M, Li M, et al. Expression of GDNF receptor (RET and GDNFR-a) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis. Brain Res 820:77-85,1999
Yamamoto M, Mitsuma N, Inukai A, et al. Expression of GDNF and GDNFR-a mRNAs in muscles of patients with motor neuron diseases. Neurochem Res 24:785-790,1999
Tanaka F, Reeves MF, Yamamoto M, et al. Tissue-specific somatic mosaicism in spinal and bulbar muscular atrophy in dependent on CAG-repeat length and androgen receptor-gene expression levels. Am J Hum Genet 65:966-973,1999
Hayakawa K, Itoh T, Yamamoto M, et al. Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristin and taxol--in vitro explant study. Neurosci Lett 274:103-106,1999
Mutoh T, Sobue G, Yamamoto M, et al. Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis. Neurochem Res 25:239-245,2000
Yoshihara T, Yamamoto M, Misu K, et al. Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease. Hum Mutat 16:177-178,2000
Kato T, Tanaka F, Yamamoto M, et al. Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes. Clin Genet 58:69-73,2000
Ito Y, Yamamoto M, Li M, et al. Temporal expression of mRNAs for neuropoietic cytokines; Interleukin-11 (IL-11), Oncostatin M (OSM), Cardiotrophin-1 (CT-1) and their receptors (IL-11Ra and OSMRb) in peripheral nerve injury. Neurochem Res 25:1113-1118,2000
Misu K, Yoshihara T, Yamamoto M, et al. An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the peripheral myelin protein zero gene (Thr124Met or Asp75Val). J Neurol Neurosurg Psychiatry 69:806-811,2000
Inukai A, Doyu M, Yamamoto M, et al. Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy msucle. Muscle Nerve 23:1421-1426,2000
Ito Y, Yamamoto M, Mitsuma N, et al. Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6) and their receptors (CNTFRa, LIFRb, IL-6Ra and gp130) in human peripheral neuropathies. Neurochem Res 26:51-58,2001
Yoshihara T, Kanda F, Yamamoto M, et al. A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot-Marie-Tooth disease type 1. J Neurol Sci 184:149-153,2001
Qiao S, Iwashita T, Yamamoto M, et al. Differential effects of LAR on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins. J Biol Chem 276:9460-9467,2001
Takeda A, Wakai M, Yamamoto M, et al. Neuronal and glial advanced glycation end product [Ne-(carboxymethyl)lysine] in Alzheimer’s disease brains. Acta Neuropathol 101:27-35,2001
Yamamoto M, Ito Y, Mitsuma N, et al. Pathology-related differential expression regulation of NGF, GDNF, CNTF and IL-6 mRNAs in human vasculitic neuropathy. Muscle Nerve 24:830-833,2001
Yamamoto M, Li M, Mitsuma N, et al. Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062. Brain Res 912:89-94,2001
Yamamoto M, Kobayashi Y, Li M, et al. In vivo gene electroporation of glial cell line-derived neurotrophic factor (GDNF) into skeletal muscle of SOD1 mutant mice. Neurochem Res 26:1201-1207,2001
Yoshihara T, Ishigaki S, Yamamoto M, et al. Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 80:158-167,2002
Yamamoto M, Ito Y, Li M, et al. Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 25:601-604,2002
Kato M, Iwashita T, Yamamoto M, et al. Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 62:2414-2422,2002
Iwai K, Yamamoto M, Yoshihara T, et al. Anticipation in familial amyotrophic lateral sclerosis with SOD1-G93S mutation. J Neurol Neurosurg Psychiatry 72:819-820,2002
Yoshihara T, Yamamoto M, Hattori N, et al. Identification of novel sequence variants in the neurofilament-light gene in the Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. J Peripher Nerv syst 7:221-224,2002
Ishigaki S, Liang Y, Yamamoto M, et al. X-linked inhibitor of apoptosis protein in mutant SOD1-mediated neuronal degeneration. J Neurochem 82:576-584,2002
Koike H, Misu K, Yamamoto M, et al. Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Arch Neurol 59:1771-1776,2002
Niwa H, Hayakawa K, Yamamoto M, et al. Differential age-dependent trophic responses of nodose, sensory, and sympathetic neurons to neurotrophins and GDNF: Potencies for neurite extension in explant culture. Neurochem Res 27:485-496,2002
Niwa J, Ishigaki S, Yamamoto M, et al. Manabu Doyu, Keiji Tanaka, Naoyuki Taniguchi, Gen Sobue: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem 277:36793-36798,2002
Ishigaki S, Niwa J, Yamamoto M, et al. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords-screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett 531:354-358,2002
Hattori N, Yamamoto M, Yoshihara T, et al. Demyelinative and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): A clinicopathologic study of 205 Japanese patients. Brain 126:134-151,2003
Ando Y, Liang Y, Yamamoto M, et al. Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR. Neurochem Res 28:839-846,2003
Lanzi C, Cassinelli G, Yamamoto M, et al. Inactivation of Ret/ptc1 oncoprotein and inhibition of papillary thyroid carcinoma cell proliferation by indolinone RPI-1. Cell Mol Life Sci 60:1449-1459,2003
Yamamoto M, Ito Y, Mitsuma N, et al. Pain-related differential expression of NGF, GDNF, IL-6, and their receptors in human vasculitic neuropathies. Intern Med 42:1100-1103,2003
Koike H, Misu K, Yamamoto M, et al. Clinicopathologic features of early- and late-onset FAP type I (FAP TTR Met30) in Japan. Amyloid 10:32-38,2003
Yamamoto M, Yoshihara T, Hattori N, et al. Glu528del in NEFL is a polymorphic variant rather than a disease-causing mutation for Charcot-Marie-Tooth disease in Japan. Neurogenetics 5:75-77,2004
Koike H, Misu K, Yamamoto M, et al. Pathologic difference of early- vs late-onset TTR Met30 familial amyloid polyneuropathy. Neurology 63:129-138,2004
Mitsuma N, Yamamoto M, Iijima M, et al. Wide range of lineages of cells expressing nerve growth factor mRNA in the nerve lesions of patients with vasculitic neuropathy: an implication of endoneurial macrophage for nerve regeneration. Neuroscience 129:109-117,2004
Koike H, Hirayama M, Yamamoto M, et al. Age-associated axonal features in HNPP with 17p11.2 deletion in Japan. J Neurol Neurosurg Psychiatry 76:1109-1114,2005
Jiang Y, Yamamoto M, Kobayashi Y, et al. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol 57:236-251,2005
Iijima M, Yamamoto M, Hirayama M, et al. Clinical and electrophysiological correlates of IVIg responsiveness in CIDP. Neurology 64:1471-1475,2005
Yamamoto M, Ishigaki S, Katsuno M, et al. Motor neuron disease up-to date. No To Shinkei 57:273-283,2005
Sone J, Hishikawa N, Yamamoto M, et al. Neuronal intranuclear hyaline inclusion disease showing motor-sensory and autonomic neuropathy. Neurology 65:1538-1543,2005

略歴

1978年3月昭和大学医学部卒業。昭和大学藤が丘病院神経内科、TBI(USA) 留学、国立長寿医療センター神経内科・臨床研究部、愛知医科大学第4内科、法務技官・医療課長、名古屋大学神経内科助教授を経て、2005年4月より心身科学部教授。名古屋大学講師(医学部非常勤)、名古屋大学遺伝カウンセリング室遺伝専門医、愛知学院大学遺伝カウンセリング部門遺伝専門医、名古屋大学神経内科分子2研究室チームリーダー

自己紹介と趣味

テニス、音楽鑑賞、ウォーキング、考えること

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